Design, synthesis, docking study and cytotoxic activity evaluation of some novel letrozole analogs daru journal of pharmaceutical sciences issn: 2008-2231. Designing, proposed synthesis and docking analysis of novel sulfonamide derivatives as antimicrobial agents ajeet 1,, arvind kumar 1 1 department of pharmaceutical chemistry and drug design, s d college of pharmacy and vocational studies, muzaffarnagar, india. Docking technique lipinski's rule and in silico am pharmacokinetic parameters are within the acceptable range defined for human use thereby indicating their potential as a drug-like molecules.
The aim of this study was to design novel multifunctional neuroprotective agents that would slow down or halt neurodegeneration through inhibition of mao-a, mao-b and caspase-3. Design, synthesis, toxicity estimation and molecular docking studies of n-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as antitubercular agents, b mathew. The computational studies on 2-phenazinamines with their protein targets have been carried out to design compounds with potential anticancer activity this stra molecular docking, g-qsar studies, synthesis and anticancer.
Docking studies were carried out during the design of gly i related analogs obtained from intermediates produced during the scale-up syntheses while performing such. Design, synthesis and molecular docking studies of some novel spiro derivatives by 1,3-cycloaddition reaction nurul syazana hasmaruddin a , hasnah osman a , nadia mohamed yusoff a , mohamed ashraf ali a,b , mohd. Indian journal of chemistry vol 51b, august 2012, pp 1105-1113 design, microwave-assisted synthesis and in silico docking studies of new 4h-pyrimido[2,1-b]benzothiazole-2-arylamino-3-cyano-4-ones as possible.
Design, synthesis, and molecular docking studies of a conjugated thiadiazole-thiourea scaffold as antituberculosis agents. Design, synthesis and docking studies of novel macrocyclic pentapeptides as anticancer multi-targeted kinase inhibitors. Synthesis, antimicrobial evaluation and docking studies of some novel quinazolinone schiff base derivatives the quinazolin-4(3h)-one structural motif possesses a wide spectrum of biological activities.
Structural docking studies and biological evaluation of some newly synthesized schiff base derived quinazolinone derivatives analogue-based design, synthesis and. Design, synthesis and docking studies of some novel isocoumarin analogues as antimicrobial agents article (pdf available) in rsc advances 4(96):53842-53853 october 2014 with 85 reads. Design, synthesis, biological and molecular docking studies of some o-hydroxycyanopyridine derivatives, ahmed h moustafa, nermin a m el-seadawy, allam a h. Qsar and structure-based docking studies of aryl pyrido[2,3-d]pyrimidin-7(8h)-ones: an attempt to anticancer drug design: 104018/ijqspr2018010103: the target of the present study has been to carry out computer-aided anticancer drug design utilizing genetic algorithm-multiple linear regression (ga-mlr.
Aim and objective: pyrazolo pyridine skeleton is an interesting class of heterocycles due to its diverse biological properties including antitumor, antioxidant and antibacterial activities the objective of this work was established in vitro antiproliferative activities against mcf-7 (breast cancer. The carboxylic acid group of ciprofloxacin was modified and amino mercapto triazole was substituted the compound was confirmed by physical parameters (solubility, melting point), chromatographic methods (tlc) and consistent with its ir & 1hnmr spectra the synthesized analogue was screened for. Design, synthesis, and docking studies of peptidomimetics based on her2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines.